Jack and Jill vs. the World

Jack and Jill vs. the World is a film by Vanessa Parise. It was released on April 4, 2008 and stars Freddie Prinze Jr. and Taryn Manning as Jack and Jill.

Jills freespirited nature causes some friction, however. When her long absences go unexplained, Jack forces Jill to confess that her disappearances are a result of the treatment she needs for cystic fibrosis, an ultimately terminal illness. Jack is furious with Jill for violating their pact of honesty, and they break up.A talk with his father Norman Forster incites Jack to find Jill. Jack tracks down her wacky friend, Lucy Parise, and pleads his case. Convinced that he truly loves Jill, Lucy admits that Jill is catching a Greyhound bus crosscountry to Hollywood. Jack reevaluates his life, and just as he quits his job, a bomb threat is called in at his work. Jack goes outside and George tells him that the bomb threat was called in by someone who wants to fight ugliness. Jack realizes that the culprit has to be Jill. The two make up, and with their new dog in tow, they hit the highway... with no destination in sight except for a life together. ........

Source: Wikipedia